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A round bottle flask containing a mixture of methyl 2-[(dimethylcarbamoyl)sulfanyl]-4-methylbenzoate (50 g, 197.6 mmol) and an aqueous solution of sodium hydroxide (120 mL, 4 N) was vacuumed and backfilled with nitrogen 3 times. After being refluxed for 2 hours, the resulting mixture was cooled to 0° C. and acidified with an aqueous solution of hydrochloric acid (45 mL, 6 N). The formed precipitate was collected by filtration, and then dissolved in ethyl acetate (500 mL). The solution was dried over anhydrous sodium sulfate, and concentrated in vacuo to afford 4-methyl-2-sulfanylbenzoic acid as a light yellow solid.

1. additionA round bottle flask containing
2. temperatureAfter being refluxed for 2 hours
3. filtrationThe formed precipitate was collected by filtration
4. dissolutiondissolved in ethyl acetate (500 mL)
5. dry with materialThe solution was dried over anhydrous sodium sulfate
6. concentrationconcentrated in vacuo