反应详情

A mixture of tert-butyl (4S)-4-[(benzylamino)methyl]-2,2-dimethyl-1,3-oxazolidine-3-carboxylate (810 mg, 2.53 mmol), palladium hydroxide on carbon (81 mg) and methanol (20 mL) was stirred at room temperature under hydrogen atmosphere overnight. The catalyst was removed by filtration. The filtrate was concentrated in vacuo. The residue was purified by SPE (12 mL tube, 2 gram of DSC-SCX) to afford the pure product.

1. customThe catalyst was removed by filtration
2. concentrationThe filtrate was concentrated in vacuo
3. customThe residue was purified by SPE (12 mL tube, 2 gram of DSC-SCX)
4. customto afford the pure product