反应详情

温度

80 °C

The mixture of 6-benzyl-8-nitro-2-oxa-6-aza-spiro[3.4]octane (2 g, 8.1 mmol), iron powder (2.3 g, 40.5 mmol), ammonium chloride (4.3 g, 81 mmol), methanol (40 mL) and 8 mL of water was heated with stirring for 2 hours at 80° C. The reaction mixture was filtered by a pad of celite. The filtrate was concentrated under reduced pressure, and the residue was used for next step without further purification.

1. temperaturewas heated
2. filtrationThe reaction mixture was filtered by a pad of celite
3. concentrationThe filtrate was concentrated under reduced pressure
4. customthe residue was used for next step without further purification