反应详情

To a solution of methyl 4-chloro-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4 (5H)-yl)quinoline-6-carboxylate (2.0 g, 4.8 mmol) in tetrahydrofuran (50 mL) was added sodium borohydride (729 mg, 19.2 mmol). After being refluxed for 60 hours, the reaction mixture was diluted with water (30 mL) and extracted with dichloromethane (50 mL×2). The combined organic layers were dried over sodium sulfate and concentrated in vacuo to afford 1.4 g of the crude product.

1. temperatureAfter being refluxed for 60 hours
2. extractionextracted with dichloromethane (50 mL×2)
3. dry with materialThe combined organic layers were dried over sodium sulfate
4. concentrationconcentrated in vacuo