2-Methylpropylenediamine → HCID 89410066, compound

HRID 540212Notes

Reaction equation

HRID 540212 reaction equation
[Cl:1][C:2]1[N:11]=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([CH3:13])[CH:8]=2)[N:3]=1.[CH3:14][C:15]([NH2:19])([CH3:18])[CH2:16][NH2:17]>CO.C(OCC)(=O)C>[Cl:1][C:2]1[N:11]=[C:10]([NH:17][CH2:16][C:15]([CH3:18])([NH2:19])[CH3:14])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([CH3:13])[CH:8]=2)[N:3]=1

Participants

5

Reactant 2

HCID 131282-MethylpropylenediamineHCID 142564832,4-Dichloro-6-methylquinazoline

Product 1

HCID 89410066HCID 89410066, compoundYield 80.6%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

A solution of 2,4-dichloro-6-methylquinazoline (500 mg, 2.35 mmol) and 2-methylpropane-1,2-diamine (365 μL, 3.52 mmol) in methanol (10 mL) was stirred at room temperature for 1 hour. The reaction mixture was diluted with ethyl acetate (30 mL) and stirred for 30 minutes. The formed solid was collected by filtration and dried in vacuo to afford 500 mg of the desired product as a white solid (yield was 80.6%).

Workup

  1. filtrationThe formed solid was collected by filtration
  2. customdried in vacuo

Sources & evidence

ORD record
ord-c1262a50852a415ebb455411ef5a78a1
Source dataset
uspto-grants-2014_10
Patent number
US08871756B2

Reaction notes

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