HRID54038

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3672

Ibuprofen

C13H18O2

结构：CCCCCCCCNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO

HCID90064

1-Deoxy-1-(octylamino)-D-glucitol

C14H31NO5

PRODUCTS

生成物

结构：CC(C)Cc1ccc([C@H](C)C(=O)O)cc1.CCCCCCCCNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO

HCID131719976

未命名化合物

收率 86%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID3776

Isopropanol

C3H8O

CONDITIONS

反应条件

温度: 33 °C

PROCEDURE

实验过程

Racemic ibuprofen (27.03, 131.03 mmol), N-octyl-D-glucamine (16.35 g, 55.73 mmol), and isopropanol (150 mL) were heated to 80° C., forming a clear solution, and the solution then cooled to 33° C. over 4 hours. The resulting precipitate was recovered by filtration, washed with isopropanol, and dried to give (S)-ibuprofen N-octyl-D-glucamine salt (23.95 g, 47.93 mmol, 73.2% yield, 99.0% ee).

WORKUP

后处理

customforming a clear solution
filtrationThe resulting precipitate was recovered by filtration
washwashed with isopropanol
customdried