Trifluoroacetic acid → HCID 178525677, compound

HRID 540396Notes

Reaction equation

HRID 540396 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].C([N:27]1[CH:31]=[C:30]([CH:32]=[CH:33][CH2:34][CH2:35][CH2:36][C:37]([OH:39])=[O:38])[N:29]=[CH:28]1)(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>ClCCl>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[NH:27]1[CH:31]=[C:30]([CH:32]=[CH:33][CH2:34][CH2:35][CH2:36][C:37]([OH:39])=[O:38])[N:29]=[CH:28]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66988303HCID 66988303, compound

Product 1

HCID 178525677HCID 178525677, compoundYield 60%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2 ml of trifluoroacetic acid are added to 0.58 g (1.37 mmol) of 6-(1-trityl-1H-imidazol-4-yl)hex-5-enoic acid in suspension in 8 ml of dichloromethane. After the solvents have been evaporated off, the oil obtained is purified on a silica column (eluent 8/2 DCM/MeOH). 240 mg of 6-(1H-imidazol-4-yl)hex-5-enoic acid trifluoroacetate in the form of a yellow oil are isolated with a yield of 60%.

Workup

  1. customAfter the solvents have been evaporated off
  2. customthe oil obtained
  3. customis purified on a silica column (eluent 8/2 DCM/MeOH)

Sources & evidence

ORD record
ord-27cf2ad7d644404f9773901f608cfebc
Source dataset
uspto-grants-2014_10
Patent number
US08871187B2

Reaction notes

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