反应详情

温度

100 °C

Methylamine (available as a 40% solution in water, 24 mL, 0.28 mol) was added to a solution of 6-benzyloxy-4-chloro-3-nitroquinoline (15.0 g, 48.5 mmol), prepared as described in Parts A-D of Example 2, in distilled water (300 mL), and the reaction was stirred at 100° C. for 1.5 hours. The reaction was allowed to cool to ambient temperature and stirred for four hours. A precipitate formed, which was isolated by filtration and washed with distilled water (3×60 mL). The solid was combined with material from another run and recrystallized from 2-propanol. The crystals were isolated by filtration, washed twice with cold hexanes, and dried for three days under high vacuum to provide 24.10 g of (6-benzyloxy-3-nitroquinolinyl)methylamine as yellow crystals.

1. customprepared
2. temperatureto cool to ambient temperature
3. stirringstirred for four hours
4. customA precipitate formed
5. customwhich was isolated by filtration
6. washwashed with distilled water (3×60 mL)
7. customrecrystallized from 2-propanol
8. customThe crystals were isolated by filtration
9. washwashed twice with cold hexanes
10. customdried for three days under high vacuum