Propylamine → HCID 58833637, compound

HRID 540940Notes

Reaction equation

HRID 540940 reaction equation
[CH2:1]([O:3][CH2:4][C:5]1[N:6]([CH2:19][C:20]([OH:23])([CH3:22])[CH3:21])[C:7]2[C:16]3[CH:15]=[CH:14][C:13]([OH:17])=[CH:12][C:11]=3[N:10]=[CH:9][C:8]=2[N:18]=1)[CH3:2].C(OC1C=[C:34]([CH:36]=CC=1)[NH2:35])C1C=CC=CC=1.N[CH2:40][C:41]([CH3:44])([OH:43])[CH3:42].[CH2:45]([O:52]NC1C=CC=CC=1)C1C=CC=CC=1.C([NH2:63])CC>>[NH2:63][C:9]1[C:8]2[N:18]=[C:5]([CH2:4][O:3][CH2:1][CH3:2])[N:6]([CH2:19][C:20]([OH:23])([CH3:22])[CH3:21])[C:7]=2[C:16]2[CH:15]=[CH:14][C:13]([O:17][CH2:36][CH2:34][NH:35][C:45](=[O:52])[O:43][C:41]([CH3:44])([CH3:42])[CH3:40])=[CH:12][C:11]=2[N:10]=1

Participants

6

Reactant 5

HCID 7852PropylamineHCID 928923-BenzyloxyanilineHCID 951022-Propanol, 1-amino-2-methyl-HCID 12589378HCID 12589378, compoundHCID 136347857HCID 136347857, compound

Product 1

HCID 58833637HCID 58833637, compound

Procedure

A modification of the methods described in Parts A-I of Example 2 was used to prepare 2-(ethoxymethyl)-1-(2-hydroxy-2-methylpropyl)-1H-imidazo[4,5-c]quinolin-7-ol, with 3-benzyloxyaniline and 1-amino-2-methylpropan-2-ol used in lieu of 4 benzyloxyaniline and propylamine, respectively.

Sources & evidence

ORD record
ord-a6cc332cd91f4e52b22065806ed33c8d
Source dataset
uspto-grants-2014_10
Patent number
US08871782B2

Reaction notes

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