Dichloromethane → Diethyl 2-amino-13-carboxy-1,14-tetradecanedicarboxylate hydrochloride

HRID 5410Notes

Reaction equation

HRID 5410 reaction equation
C(OC([NH:8][CH:9]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH:26]([C:33]([OH:35])=[O:34])[CH2:27][C:28]([O:30][CH2:31][CH3:32])=[O:29])[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=O)(C)(C)C.C(Cl)[Cl:37]>>[ClH:37].[NH2:8][CH:9]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH:26]([C:33]([OH:35])=[O:34])[CH2:27][C:28]([O:30][CH2:31][CH3:32])=[O:29])[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12]

Participants

3

Reactant 2

HCID 6344DichloromethaneHCID 19930832Diethyl 2-t-butoxycarbonylamino-13-carboxy-1,14-tetradecanedicarboxylate

Product 1

HCID 19930814Diethyl 2-amino-13-carboxy-1,14-tetradecanedicarboxylate hydrochloride

Procedure

Diethyl 2-t-butoxycarbonylamino-13-carboxy-1,14-tetradecanedicarboxylate (3.98 g, 8.40 mmol) is dissolved in methylene chloride (150.0 mL), and hydrogen chloride gas is bubbled through the solution for 15 minutes. The sealed reaction is stirred for 2.5 hours, and then the solvent is evaporated to give diethyl 2-amino-13-carboxy-1,14-tetradecanedicarboxylate hydrochloride.

Workup

  1. customhydrogen chloride gas is bubbled through the solution for 15 minutes
  2. customThe sealed reaction
  3. customthe solvent is evaporated

Sources & evidence

ORD record
ord-856e1c74c5fa4bfaa718c434d3d2dcd8
Source dataset
uspto-grants-1993_09
Patent number
US05244889

Reaction notes

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