tert-Butanol → CGP-47292 methyl ester

HRID 541032Notes

Reaction equation

HRID 541032 reaction equation
[N:1]([CH2:4][C:5]1[C:10]([F:11])=[CH:9][CH:8]=[CH:7][C:6]=1[F:12])=[N+:2]=[N-:3].Br[C:14](=[CH2:19])[C:15]([O:17][CH3:18])=[O:16].C(O)(C)(C)C>O>[F:12][C:6]1[CH:7]=[CH:8][CH:9]=[C:10]([F:11])[C:5]=1[CH2:4][N:1]1[CH:19]=[C:14]([C:15]([O:17][CH3:18])=[O:16])[N:3]=[N:2]1

Participants

5

Reactant 3

HCID 6386tert-ButanolHCID 229990Methyl 2-bromoacrylateHCID 108883232-(Azidomethyl)-1,3-difluorobenzene

Product 1

HCID 22716778CGP-47292 methyl ester

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In a preferred embodiment 2-(azidomethyl)-1,3- difluorobenzene is treated with methyl 2-bromoacrylate in mixture of t-butanol and water to produce methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate.

Sources & evidence

ORD record
ord-80c10a116cdf47a78f5ea984ecd04386
Source dataset
uspto-grants-2014_10
Patent number
US08871945B2

Reaction notes

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