HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butanol → CGP-47292 methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butanol | HCID 6386 | — |
| Reactant | Methyl 2-bromoacrylate | HCID 229990 | — |
| Reactant | 2-(Azidomethyl)-1,3-difluorobenzene | HCID 10888323 | — |
| Solvent | Water | HCID 962 | — |
| Product | CGP-47292 methyl ester | HCID 22716778 | — |
Reaction Steps
In a preferred embodiment 2-(azidomethyl)-1,3- difluorobenzene is treated with methyl 2-bromoacrylate in mixture of t-butanol and water to produce methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08871945B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-80c10a116cdf47a78f5ea984ecd04386 |
| Source note | uspto-grants-2014_10 |