Hydrochloric Acid → Cgp-47292

HRID 541035Notes

Reaction equation

HRID 541035 reaction equation
[F:1][C:2]1[CH:17]=[CH:16][CH:15]=[C:14]([F:18])[C:3]=1[CH2:4][N:5]1[CH:9]=[C:8]([C:10]([O:12]C)=[O:11])[N:7]=[N:6]1.[OH-].[Na+].Cl>O>[F:18][C:14]1[CH:15]=[CH:16][CH:17]=[C:2]([F:1])[C:3]=1[CH2:4][N:5]1[CH:9]=[C:8]([C:10]([OH:12])=[O:11])[N:7]=[N:6]1

Participants

5

Reactant 3

HCID 313Hydrochloric Acid2×HCID 14798Sodium HydroxideHCID 22716778CGP-47292 methyl ester

Product 1

HCID 10014469Cgp-47292

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of Methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate. (50 gms) and a solution of sodium hydroxide (11.76 gms in 100 ml water) were stirred at room temperature contents till it becomes clear. Hydrochloric acid (30 ml ) in DM water (70 ml) was charged to above reaction mass. Adjusted the PH of the reaction till 2-3 by adding the hydrochloric acid solution at 25-30° C. After the completion, reaction mass was filtered and dried the material at 65° C.-70° C. for 15 hours. Yield: 40 gms

Workup

  1. customAdjusted the PH of the reaction till 2-3
  2. customAfter the completion, reaction mass
  3. filtrationwas filtered
  4. customdried the material at 65° C.-70° C. for 15 hours

Sources & evidence

ORD record
ord-e066e982fd9e40da97074a9c74c3e50e
Source dataset
uspto-grants-2014_10
Patent number
US08871945B2

Reaction notes

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