反应详情

To a mixture containing N-(2-iodo-4-nitrophenyl)-N-(methylsulfonyl)methanesulfonamide (31 g; 75 mmol) in EtOH (230 ml), water (115 ml) and LiOH (9 g; 375 mmol) were added. The reaction mixture was refluxed for 2 hours, then cooled to room temperature, the solvent evaporated under reduced pressure. NH4Cl (saturated solution, 250 ml) was added and the mixture was stirred until a yellow solid precipitated. The crude product was filtered and dried under vacuum to give N-(2-iodo-4-nitrophenyl)methanesulfonamide (24 g) which was used in the following reaction without any further purification.

1. additionwere added
2. temperatureThe reaction mixture was refluxed for 2 hours
3. customthe solvent evaporated under reduced pressure
4. additionNH4Cl (saturated solution, 250 ml) was added
5. customprecipitated
6. filtrationThe crude product was filtered
7. customdried under vacuum