反应详情

Around-bottom flask, containing a solution of tert-butyl 4-(4-cyanophenyl)-5,6-dihydropyridine-1(2H)-carboxylate (compound 1.3, 500 mg, 1.76 mmol, 1.00 equiv) in ethyl acetate (20 mL) was purged with nitrogen gas. To the solution was then added palladium on carbon (0.1 g, 10%, 60% water) and the flask was then further purged with nitrogen. The atmosphere was then changed to hydrogen and the mixture was stirred overnight at room temperature. After purging the system with nitrogen, the solids were removed by filtration and the filtrate was concentrated under reduced pressure to yield 0.2 g (40%) of the title compound as a yellow oil.

1. customwas purged with nitrogen gas
2. customadded palladium on carbon (0.1 g, 10%, 60% water) and the flask was then further purged with nitrogen
3. customAfter purging the system with nitrogen
4. customthe solids were removed by filtration
5. concentrationthe filtrate was concentrated under reduced pressure