2-hydrazinyl-N,N-dimethyl-2-oxoacetamide → HCID 178424710, compound

HRID 541254Notes

Reaction equation

HRID 541254 reaction equation
[CH3:1][C:2]1[CH:23]=[C:22]([CH3:24])[C:21]([C:25]2NC(CC3CCOC3)=N[N:26]=2)=[CH:20][C:3]=1[C:4]([N:6]1[CH2:11][CH2:10][CH:9]([C:12]2[CH:19]=[CH:18][C:15]([C:16]#[N:17])=[CH:14][CH:13]=2)[CH2:8][CH2:7]1)=[O:5].[NH:36]([C:38](=O)[C:39]([N:41]([CH3:43])[CH3:42])=[O:40])[NH2:37].O1CCC(CC(NN)=O)C1>>[C:16]([C:15]1[CH:18]=[CH:19][C:12]([CH:9]2[CH2:10][CH2:11][N:6]([C:4]([C:3]3[C:2]([CH3:1])=[CH:23][C:22]([CH3:24])=[C:21]([C:25]4[NH:26][C:38]([C:39]([N:41]([CH3:43])[CH3:42])=[O:40])=[N:36][N:37]=4)[CH:20]=3)=[O:5])[CH2:7][CH2:8]2)=[CH:13][CH:14]=1)#[N:17]

Participants

4

Reactant 3

HCID 431641122-hydrazinyl-N,N-dimethyl-2-oxoacetamide2×HCID 682888162-(Tetrahydrofuran-3-yl)acetohydrazideHCID 1784247044-(1-(2,4-dimethyl-5-(5-((tetrahydrofuran-3-yl)methyl)-4H-1,2,4-triazol-3-yl)benzoyl)piperidin-4-yl)benzonitrile2×

Product 1

HCID 178424710HCID 178424710, compound

Procedure

The title compound was prepared using standard chemical manipulations and procedures similar to those used for the preparation of 4-(1-(2,4-dimethyl-5-(5-((tetrahydrofuran-3-yl)methyl)-4H-1,2,4-triazol-3-yl)benzoyl)piperidin-4-yl)benzonitrile (compound 130), using 2-hydrazinyl-N,N-dimethyl-2-oxoacetamide (compound 135.1) instead of 2-(tetrahydrofuran-3-yl)acetohydrazide (compound 130.4). m/z (ES+) 457 (M+H)+.

Sources & evidence

ORD record
ord-ff1781e95cba4ed6b37c3679dbda8d93
Source dataset
uspto-grants-2014_10
Patent number
US08871790B2

Reaction notes

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