Hydrazine hydrate (1:1) → 3-(dimethylamino)propanohydrazide

Temperature

70 °C

To a solution of methyl 3-(dimethylamino)propanoate hydrochloride (compound 142.6, 2.00 g, 15.3 mmol, 1.00 equiv) in methanol (40 mL) was added hydrazine hydrate (6 mL, 6.00 equiv). The reaction mixture was stirred at 70° C. for 3 h. The mixture was concentrated in vacuo and then dissolved in 50 mL of H2O and washed with 2×10 mL of ethyl acetate. The aqueous layers were combined and concentrated in vacuo to afford 1.30 g (65%) of 3-(dimethylamino)propanehydrazide as a colorless oil.

1. concentrationThe mixture was concentrated in vacuo
2. dissolutiondissolved in 50 mL of H2O
3. washwashed with 2×10 mL of ethyl acetate
4. concentrationconcentrated in vacuo

ORD record

ord-38488836c03c4472a7d29e9fb94b834b

Source dataset

uspto-grants-2014_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08871790B2