tert-Butyl 2-methyl-4-oxopiperidine-1-carboxylate → Tert-butyl 4-(4-bromophenyl)-4-hydroxy-2-methylpiperidine-1-carboxylate

HRID 541291Notes

Reaction equation

HRID 541291 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([OH:21])[CH2:13][CH2:12][N:11]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[CH3:22]C1CC(=O)CCN1C(OC(C)(C)C)=O>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2([OH:21])[CH2:9][CH2:10][N:11]([C:14]([O:16][C:17]([CH3:18])([CH3:20])[CH3:19])=[O:15])[CH:12]([CH3:22])[CH2:13]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 12992764tert-Butyl 2-methyl-4-oxopiperidine-1-carboxylateHCID 183795571-Boc-4-(4-bromo-phenyl)-piperidin-4-ol

Product 1

HCID 70907770Tert-butyl 4-(4-bromophenyl)-4-hydroxy-2-methylpiperidine-1-carboxylate

Procedure

The title compound was synthesized using a procedure similar to that used for the preparation of compound 1.1 and using tert-butyl 2-methyl-4-oxopiperidine-1-carboxylate in place of tert-butyl 4-oxopiperidine-1-carboxylate.

Sources & evidence

ORD record
ord-7b331fe34c9e4ea798a677a56944ce5f
Source dataset
uspto-grants-2014_10
Patent number
US08871790B2

Reaction notes

Loading…