4-Bromo-2-fluorobenzoic acid → 4-Bromo-2-ethylbenzoic acid

To a 1 L three neck round-bottom flask, which was purged and maintained with a nitrogen atmosphere, was added 4-bromo-2-fluorobenzoic acid (50.0 g, 228 mmol, 1.00 equiv) in tetrahydrofuran (500 mL). A solution of ethylmagnesium bromide (250 mL, 3 M in THF) was added dropwise at 0° C. The resulting solution was stiffed for 3-4 h at 0° C. The mixture was then carefully quenched by dropwise addition of water at 0° C. After complete quench of the reaction, additional water was added and the pH was adjusted to 2-3 with hydrogen chloride (aqueous, 2 M). The mixture was extracted with 2×200 mL of ethyl acetate and the organic layers were combined. Sodium hydroxide (2N, aq.) was employed to adjust the pH to 7-8. The resulting mixture was washed with 2×200 mL of ethyl acetate. The pH value of the aqueous solution was adjusted to 2-3 with 2N hydrogen chloride, then extracted with 2×200 mL of ethyl acetate. The combined organic layers were dried over anhydrous sodium sulfate and concentrated in vacuo. This resulted in 30.0 g (57%) of 4-bromo-2-ethylbenzoic acid as a yellow solid.

1. customTo a 1 L three neck round-bottom flask, which was purged
2. temperaturemaintained with a nitrogen atmosphere
3. customThe mixture was then carefully quenched by dropwise addition of water at 0° C
4. customAfter complete quench of the reaction, additional water
5. additionwas added
6. extractionThe mixture was extracted with 2×200 mL of ethyl acetate
7. washThe resulting mixture was washed with 2×200 mL of ethyl acetate
8. extractionextracted with 2×200 mL of ethyl acetate
9. dry with materialThe combined organic layers were dried over anhydrous sodium sulfate
10. concentrationconcentrated in vacuo
11. customThis resulted in 30.0 g (57%) of 4-bromo-2-ethylbenzoic acid as a yellow solid

ORD record

ord-6afbb870c017466698f6433112c3e82a

Source dataset

uspto-grants-2014_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08871790B2