Hydrochloric Acid → HCID 178494305, compound

HRID 541367Notes

Reaction equation

HRID 541367 reaction equation
[CH:1]1([C:5]2[C:26]([C:27]3[NH:31][C:30]([O:32][CH3:33])=[N:29][N:28]=3)=[CH:25][C:8]([C:9]([N:11]3[CH2:16][CH2:15][CH:14]([C:17]4[CH:24]=[CH:23][C:20]([C:21]#[N:22])=[CH:19][CH:18]=4)[CH2:13][CH2:12]3)=[O:10])=[C:7]([CH3:34])[CH:6]=2)[CH2:4][CH2:3][CH2:2]1.Cl.[F:36]C1(C2C=CC(C#N)=CC=2)CCNCC1.Cl>>[CH:1]1([C:5]2[C:26]([C:27]3[NH:31][C:30]([O:32][CH3:33])=[N:29][N:28]=3)=[CH:25][C:8]([C:9]([N:11]3[CH2:12][CH2:13][C:14]([C:17]4[CH:18]=[CH:19][C:20]([C:21]#[N:22])=[CH:23][CH:24]=4)([F:36])[CH2:15][CH2:16]3)=[O:10])=[C:7]([CH3:34])[CH:6]=2)[CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 682888554-(4-Fluoropiperidin-4-yl)benzonitrile hydrochlorideHCID 178494304HCID 178494304, compound2×

Product 1

HCID 178494305HCID 178494305, compound

Procedure

The title compound was prepared using standard chemical manipulations and procedures similar to those used for the preparation of 4-(1-(4-cyclobutyl-5-(5-methoxy-4H-1,2,4-triazol-3-yl)-2-methylbenzoyl)piperidin-4-yl)benzonitrile (compound 222) but using compound 11.2 HCl salt in place of compound 1.5. m/z (ES+) 474 (M+H)+.

Sources & evidence

ORD record
ord-dc3057223a9a4e7d9e87750861ff4287
Source dataset
uspto-grants-2014_10
Patent number
US08871790B2

Reaction notes

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