HCID 19961156, compound → 5,6-Dihydroxy-1-(N-methyl)aminomethyl-3-phenyl-3,4-dihydronaphthalene

HRID 54140Notes

Reaction equation

HRID 54140 reaction equation
[NH2:1][CH2:2][C:3]1[C:12]2[C:7](=[C:8]([O:15]C)[C:9]([O:13]C)=[CH:10][CH:11]=2)[CH2:6][CH:5]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:4]=1.Cl.N[CH2:25]C1C2C(=C(OC)C(OC)=CC=2)CC(C2C=CC=CC=2)C=1>>[OH:15][C:8]1[C:9]([OH:13])=[CH:10][CH:11]=[C:12]2[C:7]=1[CH2:6][CH:5]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[CH:4]=[C:3]2[CH2:2][NH:1][CH3:25]

Participants

3

Reactant 2

HCID 19961156HCID 19961156, compoundHCID 199611571-Aminomethyl-5,6-dimethoxy-3-phenyl-3,4-dihydronaphthalene

Product 1

HCID 199611965,6-Dihydroxy-1-(N-methyl)aminomethyl-3-phenyl-3,4-dihydronaphthalene

Procedure

1-Aminomethyl-5,6-dimethoxy-3-phenyl-3,4-dihydronaphthalene, the product of Step 2 of Example 2, was N-methylated as described in Example 111 and deprotected as described in Step 4 of Example 2 to give the title compound as its hydrochloride salt, m.p. 131°-133° C.; DCI MS: 282 (M+H)+. Analysis calculated for C18H20ClNO2 : C, 68.03; H, 6.34; N, 4.41. Found: C, 67.64; H, 6.54; N, 4.31.

Sources & evidence

ORD record
ord-1b22fb7e0867494b88b4a5016bacffc8
Source dataset
uspto-grants-1997_04
Patent number
US05621133

Reaction notes

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