3,4-Diaminopyridine → HCID 86672543, compound

HRID 541411Notes

Reaction equation

HRID 541411 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[CH:18]=[CH:19][C:20]([CH3:31])=[C:21]([NH:23][C:24]([N:26]4[CH:30]=[CH:29][N:28]=[CH:27]4)=[S:25])[CH:22]=3)=[O:16])[CH2:11][CH2:10]2)=[CH:5][CH:4]=1)#[N:2].[N:32]1C=CC(N)=[C:34](N)[CH:33]=1>CN(C=O)C>[NH2:32][C:33]1[CH:34]=[CH:27][N:28]=[CH:29][C:30]=1[NH:26][C:24]([NH:23][C:21]1[CH:22]=[C:17]([C:15]([N:12]2[CH2:13][CH2:14][CH:9]([C:6]3[CH:7]=[CH:8][C:3]([C:1]#[N:2])=[CH:4][CH:5]=3)[CH2:10][CH2:11]2)=[O:16])[CH:18]=[CH:19][C:20]=1[CH3:31])=[S:25]

Participants

4

Reactant 2

HCID 59183,4-DiaminopyridineHCID 86672544HCID 86672544, compound

Product 1

HCID 86672543HCID 86672543, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of N-(5-(4-(4-cyanophenyl)piperidine-1-carbonyl)-2-methylphenyl)-1H-imidazole-1-carbothioamide (281.1) in DMF continued from the prior step was added pyridine-3,4-diamine (0.034, 0.32 mmol). The mixture was stirred at room temperature for 3 hours. LCMS showed the reaction was complete. The reaction was carried to the next step without workup or purification. m/z (ES+) 471 (M+H)+.

Workup

  1. customThe reaction was carried to the next step without workup or purification

Sources & evidence

ORD record
ord-1ebde4c9d805455e9c3b6edf95ec1f16
Source dataset
uspto-grants-2014_10
Patent number
US08871790B2

Reaction notes

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