Sodium Hydroxide → 4-Amino-5-methylpicolinic acid

참여 물질

반응 단계

A solution of methyl 4-amino-5-methylpicolinate (compound 349.3, 1.50 g, 8.12 mmol, 1.00 equiv, 90%) and 5N sodium hydroxide (aq., 15 mL) in methanol (15 mL) was stiffed overnight at room temperature, then concentrated under reduced pressure. The residue was diluted with 20 mL of H2O and the pH was adjusted to 3-4 with 2 M aqueous hydrogen chloride. The resulting precipitate was collected by filtration and dried to yield 0.8 g (58%) of the title compound as a yellow solid.

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