Sodium Hydroxide → 4-Amino-5-methylpicolinic acid

HRID 541423노트

반응식

HRID 541423 반응식
[NH2:1][C:2]1[C:7]([CH3:8])=[CH:6][N:5]=[C:4]([C:9]([O:11]C)=[O:10])[CH:3]=1.[OH-].[Na+]>CO>[NH2:1][C:2]1[C:7]([CH3:8])=[CH:6][N:5]=[C:4]([C:9]([OH:11])=[O:10])[CH:3]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 68288436HCID 68288436, 화합물2회

생성물 1

HCID 450820444-Amino-5-methylpicolinic acid수율 64.8%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of methyl 4-amino-5-methylpicolinate (compound 349.3, 1.50 g, 8.12 mmol, 1.00 equiv, 90%) and 5N sodium hydroxide (aq., 15 mL) in methanol (15 mL) was stiffed overnight at room temperature, then concentrated under reduced pressure. The residue was diluted with 20 mL of H2O and the pH was adjusted to 3-4 with 2 M aqueous hydrogen chloride. The resulting precipitate was collected by filtration and dried to yield 0.8 g (58%) of the title compound as a yellow solid.

후처리

  1. concentrationconcentrated under reduced pressure
  2. additionThe residue was diluted with 20 mL of H2O
  3. filtrationThe resulting precipitate was collected by filtration
  4. customdried

출처 및 근거

ORD 기록
ord-3a8911cd855448e597ea00fc6f2df2bd
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08871790B2

반응 노트

불러오는 중…