Phenyl chloroformate → HCID 14503897, compound

Temperature

-40 °C

A 3-L four neck round-bottom flask was purged and maintained with a nitrogen atmosphere and a solution of 4-methoxypyridine (30.0 g, 275 mmol, 1.00 equiv) in tetrahydrofuran (1.2 L) was added. The mixture was cooled to −40° C. and phenyl chloroformate (45.0 g, 287 mmol, 1.05 equiv) was added dropwise. The resulting solution was stirred for 1 h at −40° C., then methylmagnesium bromide (3M, 110 mL, 1.20 equiv) was added to the reaction mixture while maintaining the temperature at −40° C. The resulting solution was warmed slowly to 5-10° C. and stirred for 2 h, then carefully quenched with ice water (100 mL). The resulting mixture was extracted with ethyl acetate (2×1 L) and the combined organics was washed with brine (1×300 mL), dried (Na2SO4), filtered and concentrated in vacuo to yield the title compound as a light brown oil (71.0 g, >theoretical).

1. customA 3-L four neck round-bottom flask was purged
2. temperaturemaintained with a nitrogen atmosphere
3. temperaturewhile maintaining the temperature at −40° C
4. temperatureThe resulting solution was warmed slowly to 5-10° C.
5. stirringstirred for 2 h
6. customcarefully quenched with ice water (100 mL)
7. extractionThe resulting mixture was extracted with ethyl acetate (2×1 L)
8. washthe combined organics was washed with brine (1×300 mL)
9. dry with materialdried (Na2SO4)
10. filtrationfiltered
11. concentrationconcentrated in vacuo

ORD record

ord-0e46fdecc5944090be3d423f3345908c

Source dataset

uspto-grants-2014_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08871790B2