참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 3-Aminostyrene | HCID 4260041 | — |
| 반응물 | 2,5-dichloro-N-(3-vinylphenyl)pyrimidin-4-amine trifluoroacetate | HCID 86636129 | — |
| 용매 | Hydrochloric Acid | HCID 313 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | 2-Methoxyethanol | HCID 8019 | — |
| 생성물 | Trifluoroacetate | HCID 84468 | 474% |
| 생성물 | 5-Chloro-N,N'-bis(3-vinylphenyl)pyrimidine-2,4-diamine Trifluoroacetate | HCID 66879698 | — |
반응 단계
A solution of 2,5-dichloro-N-(3-vinylphenyl)pyrimidin-4-amine trifluoroacetate (150 mg, 0.56 mmol) and 3-vinylaniline (200 mg, 1.0 mmol) in 2-methoxyethanol (3.8 mL) and 3 N hydrogen chloride in ethanol (0.56 mL) were mixed and heated to 150° C. for 30 minutes in a microwave. Purification by preparative LCMS (pH 2) gave the desired product as a trifluoroacetate salt (150 mg, 60%). LCMS for C20H17ClN4 (M+H)+: m/z=349.1.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08871753B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_10 |
|---|
| ORD ID | ord-8cee1e93a93c4a89adb37374b149650d |
|---|
| 출처 메모 | uspto-grants-2014_10 |
|---|
