反应详情

温度

150 °C

A solution of 2,5-dichloro-N-(3-vinylphenyl)pyrimidin-4-amine trifluoroacetate (150 mg, 0.56 mmol) and 3-vinylaniline (200 mg, 1.0 mmol) in 2-methoxyethanol (3.8 mL) and 3 N hydrogen chloride in ethanol (0.56 mL) were mixed and heated to 150° C. for 30 minutes in a microwave. Purification by preparative LCMS (pH 2) gave the desired product as a trifluoroacetate salt (150 mg, 60%). LCMS for C20H17ClN4 (M+H)+: m/z=349.1.

1. customPurification by preparative LCMS (pH 2)