5-Bromo-2,4-dichloropyrimidine → HCID 57961712, compound

HRID 541746Notes

Reaction equation

HRID 541746 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH2:16][CH2:17][C:18]2[CH:19]=[C:20]([NH:24][C:25](=[O:31])[O:26][C:27]([CH3:30])([CH3:29])[CH3:28])[CH:21]=[CH:22][CH:23]=2)[CH:5]=[C:6]([S:8]([NH:11][C:12]([CH3:15])([CH3:14])[CH3:13])(=[O:10])=[O:9])[CH:7]=1.[Br:32][C:33]1[C:34](Cl)=[N:35][C:36]([Cl:39])=[N:37][CH:38]=1>>[Br:32][C:33]1[C:34]([NH:1][C:2]2[CH:3]=[C:4]([CH2:16][CH2:17][C:18]3[CH:19]=[C:20]([NH:24][C:25](=[O:31])[O:26][C:27]([CH3:30])([CH3:29])[CH3:28])[CH:21]=[CH:22][CH:23]=3)[CH:5]=[C:6]([S:8]([NH:11][C:12]([CH3:14])([CH3:15])[CH3:13])(=[O:10])=[O:9])[CH:7]=2)=[N:35][C:36]([Cl:39])=[N:37][CH:38]=1

Participants

3

Reactant 2

HCID 2899735-Bromo-2,4-dichloropyrimidineHCID 57962385HCID 57962385, compound

Product 1

HCID 57961712HCID 57961712, compoundYield 44%

Procedure

The desired compound was prepared according to the procedure of Example B5, step G using tert-butyl [3-(2-{3-amino-5-[(tert-butylamino)sulfonyl]phenyl}ethyl)phenyl]carbamate and 5-bromo-2,4-dichloropyrimidine as the starting materials in 44% yield. LCMS for C27H33BrClN5O4SNa (M+Na)+: m/z=660.3, 662.3.

Sources & evidence

ORD record
ord-e3dc88a65a05487dab928fde364098db
Source dataset
uspto-grants-2014_10
Patent number
US08871753B2

Reaction notes

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