1-Methyl-1H-imidazole-5-carbonyl chloride hydrochloride → HCID 69017448, compound

HRID 541777Notes

Reaction equation

HRID 541777 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].FC(F)(F)C(O)=O.[Cl:15][C:16]1[CH:17]=[N:18][C:19]2[NH:20][C:21]3[CH:22]=[CH:23][CH:24]=[C:25]([CH:38]=3)[CH2:26][CH2:27][C:28]3[CH:36]=[C:32]([NH:33][C:34]=1[N:35]=2)[CH:31]=[C:30]([NH2:37])[CH:29]=3.Cl.[CH3:40][N:41]1[C:45]([C:46](Cl)=[O:47])=[CH:44][N:43]=[CH:42]1>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[Cl:15][C:16]1[CH:17]=[N:18][C:19]2[NH:20][C:21]3[CH:22]=[CH:23][CH:24]=[C:25]([CH:38]=3)[CH2:26][CH2:27][C:28]3[CH:36]=[C:32]([NH:33][C:34]=1[N:35]=2)[CH:31]=[C:30]([NH:37][C:46]([C:45]1[N:41]([CH3:40])[CH:42]=[N:43][CH:44]=1)=[O:47])[CH:29]=3

Participants

3

Reactant 2

HCID 27765531-Methyl-1H-imidazole-5-carbonyl chloride hydrochlorideHCID 866362556-Chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-11-amine bis(trifluoroacetate)

Product 1

HCID 69017448HCID 69017448, compoundYield 29%

Procedure

The desired compound was prepared according to the procedure of Example B26, using 6-chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-11-amine bis(trifluoroacetate) and 1-methyl-1H-imidazole-5-carbonyl chloride hydrochloride as the starting materials in 29% yield. LCMS for C23H21ClN7O (M+H)+: m/z=446.2.

Sources & evidence

ORD record
ord-aed57b6bb4b7431e97b73c14a010e462
Source dataset
uspto-grants-2014_10
Patent number
US08871753B2

Reaction notes

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