Hydrochloric Acid → N-(3-Aminobenzyl)-3-nitrobenzamide Hydrochloride

HRID 541815Notes

Reaction equation

HRID 541815 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH:25]=[CH:26][CH:27]=1)[C:7]([NH:9][CH2:10][C:11]1[CH:12]=[C:13]([NH:17]C(=O)OC(C)(C)C)[CH:14]=[CH:15][CH:16]=1)=[O:8])([O-:3])=[O:2].[ClH:28]>O1CCOCC1>[ClH:28].[NH2:17][C:13]1[CH:12]=[C:11]([CH:16]=[CH:15][CH:14]=1)[CH2:10][NH:9][C:7](=[O:8])[C:6]1[CH:25]=[CH:26][CH:27]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57961674HCID 57961674, compound

Product 1

HCID 66880486N-(3-Aminobenzyl)-3-nitrobenzamide Hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

tert-butyl (3-{[(3-nitrobenzoyl)amino]methyl}phenyl)carbamate (1.00 g, 2.69 mmol) was mixed with 4 M of hydrogen chloride in 1,4-dioxane (10 mL) and stirred at rt for 2 h. After concentration, the desired product was isolated as a white powder (0.82 grams, 99% yield) and used in the next step without further purification. MF=C14H13N3O3; LCMS calculated for C14H13N3O3 (M+H)+: m/z=272.0. 1H NMR (400 MHz, CD3OD): δ 8.73 (t, J=2.0 Hz, 1H), 8.42 (ddd, J=8.4, 2.4, 1.2 Hz, 1H), 8.28 (ddd, J=8.0, 2.4, 1.2 Hz, 1H), 7.76 (t, J=8.4 Hz, 1H), 7.52 (m, 2H), 7.45 (s, 1H), 7.31 (ddd, J=8.4, 2.0, 1.2, 1H), 4.66 (s, 2H).

Workup

  1. concentrationAfter concentration

Sources & evidence

ORD record
ord-87682015c6f24036bc1b8cdf0f317aa6
Source dataset
uspto-grants-2014_10
Patent number
US08871753B2

Reaction notes

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