Hydrochloric Acid → N-(3-Aminophenyl)-1-(3-nitrophenyl)methanesulfonamide Hydrochloride

HRID 541828Notes

Reaction equation

HRID 541828 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH:26]=[CH:27][CH:28]=1)[CH2:7][S:8]([NH:11][C:12]1[CH:13]=[C:14]([NH:18]C(=O)OC(C)(C)C)[CH:15]=[CH:16][CH:17]=1)(=[O:10])=[O:9])([O-:3])=[O:2].[ClH:29]>O1CCOCC1>[ClH:29].[NH2:18][C:14]1[CH:13]=[C:12]([NH:11][S:8]([CH2:7][C:6]2[CH:26]=[CH:27][CH:28]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=2)(=[O:9])=[O:10])[CH:17]=[CH:16][CH:15]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86636267HCID 86636267, compound

Product 1

HCID 66881065N-(3-Aminophenyl)-1-(3-nitrophenyl)methanesulfonamide Hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

tert-Butyl (3-{[(3-nitrobenzyl)sulfonyl]amino}phenyl)carbamate (0.50 g, 1.2 mmol) and 4.0 M of hydrogen chloride were dissolved in 1,4-dioxane (3 mL) and stirred at rt for 2 h. The solvent was removed under vacuum and the white powder product (0.37 g, 98%) as a HCl salt was used in the next step without further purification. LCMS for C13H13N3O4S (M+H)+: m/z=308.0.

Workup

  1. customThe solvent was removed under vacuum
  2. customthe white powder product (0.37 g, 98%) as a HCl salt was used in the next step without further purification

Sources & evidence

ORD record
ord-33fcf9fc0c8b47fd8b906adb8e8f24eb
Source dataset
uspto-grants-2014_10
Patent number
US08871753B2

Reaction notes

Loading…