反应详情

温度

40 °C

To a mixture of tert-butyl [4-(2-{3-[(2-chloro-5-fluoropyrimidin-4-yl)amino]phenyl}ethyl)pyridin-2-yl]carbamate (88 mg, 0.20 mmol) in 1,4-dioxane (0.50 mL) was added 4 M hydrogen chloride in 1,4-dioxane (2.0 mL). The resultant reaction mixture was stirred at 40° C. for 1 hour. The reaction mixture was concentrated under vacuum to give the desired product as a very hygroscopic white powder (83 mg, 100%). LCMS for C17H16ClFN5 (M+H)+: m/z=344.1.

1. customThe resultant reaction mixture
2. concentrationThe reaction mixture was concentrated under vacuum