Hydrochloric Acid → N-{3-[2-(5-Aminopyridin-3-yl)ethyl]phenyl}-2,5-dichloropyrimidin-4-amine dihydrochloride

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Reaction Steps

Into the reaction vessel were added tert-butyl [5-(2-{3-[(2,5-dichloropyrmidin-4-yl)amino]phenyl}ethyl)pyridin-3-yl]carbamate (0.20 g, 0.43 mmol) and methanol (2.0 mL) and 4.0 M hydrogen chloride in 1,4-dioxane (2.0 mL). The reaction mixture was stirred at rt for 2 h and then concentrated under vacuum to give the desired product as an off-white powder (140 mg, 96%). LCMS for C17H16Cl2N5 (M+H)+: m/z=360.0, 362.0.

Provenance & Evidence