反应详情

Into the reaction vessel were added tert-butyl [5-(2-{3-[(2,5-dichloropyrmidin-4-yl)amino]phenyl}ethyl)pyridin-3-yl]carbamate (0.20 g, 0.43 mmol) and methanol (2.0 mL) and 4.0 M hydrogen chloride in 1,4-dioxane (2.0 mL). The reaction mixture was stirred at rt for 2 h and then concentrated under vacuum to give the desired product as an off-white powder (140 mg, 96%). LCMS for C17H16Cl2N5 (M+H)+: m/z=360.0, 362.0.

1. concentrationconcentrated under vacuum