Hydrochloric Acid → HCID 66897337, compound

HRID 541874Notes

Reaction equation

HRID 541874 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH:23]=[CH:24][CH:25]=1)[CH2:7][NH:8][C:9]1[CH:10]=[C:11]([NH:15]C(=O)OC(C)(C)C)[CH:12]=[CH:13][CH:14]=1)([O-:3])=[O:2].[ClH:26]>O1CCOCC1>[ClH:26].[ClH:26].[N+:1]([C:4]1[CH:5]=[C:6]([CH:23]=[CH:24][CH:25]=1)[CH2:7][NH:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([NH2:15])[CH:10]=1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57961759HCID 57961759, compound

Product 1

HCID 66897337HCID 66897337, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

tert-Butyl {3-[(3-nitrobenzyl)amino]phenyl}carbamate (7.15 g, 0.021 mol) was mixed with 4 M of hydrogen chloride in 1,4-dioxane (68.3 mL) and stirred at rt for 1 hour and concentrated to give the desired product (6.32 g, 96%) as an off-white powder. LCMS for C13H14N3O2 (M+H)+: m/z=244.1.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-e2fc18f6bc9c4595b0eaec6e8d42238e
Source dataset
uspto-grants-2014_10
Patent number
US08871753B2

Reaction notes

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