反应详情

Into the reaction flask was added tert-butyl [5-(2-{2-[(tert-butoxycarbonyl)amino]-5-[(2-chloro-5-methylpyrimidin-4-yl)amino]phenyl}ethyl)pyridin-3-yl]carbamate (0.030 g, 0.054 mmol), methanol (0.6 mL), and 4.0 M of hydrogen chloride in 1,4-dioxane (1 mL). The mixture was stirred at rt overnight and concentrated to give the desired product (21 mg, 95%). LCMS for C18H20ClN6 (M+H)+: m/z=355.1.

1. concentrationconcentrated