反应详情

温度

70 °C

To a suspension of 3-iodo-4-nitrophenyl methyl ether (5.0 g, 0.018 mol) in methanol (50 mL), water (5 mL), and acetic acid (10 mL) was added iron (3.00 g, 0.0538 mol) powder in small quantities. When the addition was completed, the reaction mixture was heated at 70° C. overnight. After filtration, the cake was rinsed with EtOAc. The filtrate was concentrated and the residue was diluted with NaHCO3 (aq) and EtOAc. After layer separation, the organic layer was dried, filtered and concentrated to give the desired product (4.0 g, 90%).

1. additionWhen the addition
2. filtrationAfter filtration
3. washthe cake was rinsed with EtOAc
4. concentrationThe filtrate was concentrated
5. additionthe residue was diluted with NaHCO3 (aq) and EtOAc
6. customAfter layer separation
7. customthe organic layer was dried
8. filtrationfiltered
9. concentrationconcentrated