HRID541962

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11275982

tert-butyl 3-ethynylphenylcarbamate

C13H15NO2

结构：C[Si](C)(C)CCOC(=O)NC1CCN(c2ccc([N+](=O)[O-])cc2Br)C1

HCID66879729

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)Nc1cccc(C#Cc2cc([N+](=O)[O-])ccc2N2CCC(NC(=O)OCC[Si](C)(C)C)C2)c1

HCID86636303

未命名化合物

收率 91%

PROCEDURE

实验过程

The desired compound was prepared according to the procedure of Example A11, step C, using 2-(trimethylsilyl)ethyl [1-(2-bromo-4-nitrophenyl)pyrrolidin-3-yl]carbamate and tert-butyl (3-ethynylphenyl)carbamate as the starting materials in 91% yield. LCMS for C29H39N4O6Si (M+H)+: m/z=567.2.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0db4fc9ce6ec44cca7e5d24e1b2d1d02
来源数据集: uspto-grants-2014_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08871753B2
来源说明: uspto-grants-2014_10

反应 SMILES

Br[C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[N:11]1[CH2:15][CH2:14][CH:13]([NH:16][C:17](=[O:25])[O:18][CH2:19][CH2:20][Si:21]([CH3:24])([CH3:23])[CH3:22])[CH2:12]1.[C:26]([C:28]1[CH:29]=[C:30]([NH:34][C:35](=[O:41])[O:36][C:37]([CH3:40])([CH3:39])[CH3:38])[CH:31]=[CH:32][CH:33]=1)#[CH:27]>>[C:37]([O:36][C:35]([NH:34][C:30]1[CH:29]=[C:28]([C:26]#[C:27][C:2]2[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=2[N:11]2[CH2:15][CH2:14][CH:13]([NH:16][C:17](=[O:25])[O:18][CH2:19][CH2:20][Si:21]([CH3:24])([CH3:23])[CH3:22])[CH2:12]2)[CH:33]=[CH:32][CH:31]=1)=[O:41])([CH3:40])([CH3:39])[CH3:38]