Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
tert-Butyl 3-ethynylphenylcarbamate → 2-(Trimethylsilyl)ethyl {1-[2-({3-[(tert-butoxycarbonyl)amino]phenyl}ethynyl)-4-nitrophenyl]pyrrolidin-3-yl}carbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | tert-Butyl 3-ethynylphenylcarbamate | HCID 11275982 | — |
| 반응물 | 2-(Trimethylsilyl)ethyl [1-(2-bromo-4-nitrophenyl)pyrrolidin-3-yl]carbamate | HCID 66879729 | — |
| 생성물 | 2-(Trimethylsilyl)ethyl {1-[2-({3-[(tert-butoxycarbonyl)amino]phenyl}ethynyl)-4-nitrophenyl]pyrrolidin-3-yl}carbamate | HCID 86636303 | 91% |
반응 단계
The desired compound was prepared according to the procedure of Example A11, step C, using 2-(trimethylsilyl)ethyl [1-(2-bromo-4-nitrophenyl)pyrrolidin-3-yl]carbamate and tert-butyl (3-ethynylphenyl)carbamate as the starting materials in 91% yield. LCMS for C29H39N4O6Si (M+H)+: m/z=567.2.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08871753B2 |
| 출처 데이터셋 | uspto-grants-2014_10 |
| ORD ID | ord-0db4fc9ce6ec44cca7e5d24e1b2d1d02 |
| 출처 메모 | uspto-grants-2014_10 |