Benzenesulfonyl isocyanate, 2-chloro- → HCID 13269839, compound

HRID 542096Notes

Reaction equation

HRID 542096 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([CH:8]([O:11][CH3:12])[O:9][CH3:10])[CH:5]=[C:4]([CH3:13])[N:3]=1.[Cl:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[S:21]([N:24]=[C:25]=[O:26])(=[O:23])=[O:22]>CCOCC>[Cl:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[S:21]([NH:24][C:25]([NH:1][C:2]1[N:7]=[C:6]([CH:8]([O:11][CH3:12])[O:9][CH3:10])[CH:5]=[C:4]([CH3:13])[N:3]=1)=[O:26])(=[O:23])=[O:22]

Participants

4

Reactant 2

HCID 174071Benzenesulfonyl isocyanate, 2-chloro-HCID 137695754-(Dimethoxymethyl)-6-methylpyrimidin-2-amine

Product 1

HCID 13269839HCID 13269839, compoundYield 76.2%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A solution of 0.3 g of 2-amino-4-dimethoxymethyl-6-methylpyrimidine in 50 ml of ether was stirred overnight at room temperature with 0.46 g of o-chlorobenzenesulfonyl isocyanate. The product was filtered and washed with hexane to provide 0.5 g of the title compound, m.p. 150°-153°.

Workup

  1. filtrationThe product was filtered
  2. washwashed with hexane

Sources & evidence

ORD record
ord-3f84653693744feb80abcf852a55cf67
Source dataset
uspto-grants-1987_04
Patent number
US04655823

Reaction notes

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