Methyl iodide → HCID 13882870, compound

HRID 542110Notes

Reaction equation

HRID 542110 reaction equation
[Cl:1][C:2]([F:20])([F:19])[C:3]1[N:8]=[C:7]([C:9]([F:12])([F:11])[F:10])[C:6]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[C:5]([OH:18])[CH:4]=1.[C:21]([O-])([O-])=O.[K+].[K+].CI>CC(C)=O>[Cl:1][C:2]([F:19])([F:20])[C:3]1[N:8]=[C:7]([C:9]([F:12])([F:10])[F:11])[C:6]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[C:5]([O:18][CH3:21])[CH:4]=1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 178470033HCID 178470033, compound

Product 1

HCID 13882870HCID 13882870, compoundYield 88.4%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

This compound was prepared using the procedure of Example 8, 12.0 g (0.038 mol) of product of Example 5, 5.8 g (0.042 mol) of K2CO3, 12 ml (0.190 mol) of methyl iodide in 200 ml of acetone were reacted affording 11.21 g of solid which was purified by HPLC using 25% ethyl acetate/cyclohexane as eluting solvent to give 9.33 g (73.6%) of product as a white solid; mp 62°-64° C.

Workup

  1. customThis compound was prepared
  2. customwere reacted

Sources & evidence

ORD record
ord-db5d0de3aa574b6db5cbea2a865c8906
Source dataset
uspto-grants-1987_04
Patent number
US04655816

Reaction notes

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