Methanol → HCID 807879, compound

HRID 542159Notes

Reaction equation

HRID 542159 reaction equation
CO.[CH2:3]([O:10][C:11]1[CH:20]=[CH:19][C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:12]=1[CH:21]=O)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.C([O-])(=O)C.[Na+].Cl.[NH2:29][OH:30]>O>[CH2:3]([O:10][C:11]1[CH:20]=[CH:19][C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:12]=1[CH:21]=[N:29][OH:30])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

6

Reactant 4

HCID 887MethanolHCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 7354602-(benzyloxy)-1-naphthaldehyde

Product 1

HCID 807879HCID 807879, compoundYield 97.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

To 460 ml of methanol and 150 ml of water were added 120 g (0.46 mole) of 2-benzyloxy-1-naphthaldehyde, 75 g (0.92 mole) of sodium acetate and 48 g (0.69 mole) of hydroxylamine hydrochloride, and the mixture was refluxed by heating for 2 hours. After the reaction, the reaction mixture was added to 1.5 liters of water. The precipitated crystals were collected by filtration to obtain 125 g (0.45 mole) of 2-benzyloxy-1-naphthaldoxime.

Workup

  1. temperaturethe mixture was refluxed
  2. temperatureby heating for 2 hours
  3. customAfter the reaction
  4. filtrationThe precipitated crystals were collected by filtration

Sources & evidence

ORD record
ord-850a7c4a3b794305959c5eedfa442172
Source dataset
uspto-grants-1987_04
Patent number
US04656126

Reaction notes

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