Hydrochloric Acid → HCID 13051346, compound

HRID 542166Notes

Reaction equation

HRID 542166 reaction equation
Cl.C[O:3][C:4]1[CH:16]=[CH:15][C:7]2[NH:8][C:9]([CH3:14])=[N:10][S:11](=[O:13])(=[O:12])[C:6]=2[CH:5]=1>>[OH:3][C:4]1[CH:16]=[CH:15][C:7]2[NH:8][C:9]([CH3:14])=[N:10][S:11](=[O:13])(=[O:12])[C:6]=2[CH:5]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 13051345HCID 13051345, compound

Product 1

HCID 13051346HCID 13051346, compoundYield 74.6%

Procedure

HCl (20 g) is heated to 210° C. and 5 g of 7-methoxy-3-methyl-4H-1,2,4-benzothiadiazine-1, 1-dioxide are added. This mixture was kept at about 210° C. for about 11/2 hours. The mixture was then cooled slightly and about 60 ml of ice cold water was added with stirring. This mixture was filtered and the solid washed with 25 ml. of cold water and dried yielding 3.5 g of 7-hydroxy-3-methyl-4H-1,2,4-benzothiadiazine-1,1-dioxide (A). An additional 0.63 g of A was recovered from the filtrate to allowing it to stand in the refrigerator for about one hour. Total yield of this product was 4.13 g (88%), m.p. 333°-336° C. (dec.).

Workup

  1. customwas kept at about 210° C. for about 11
  2. custom2 hours
  3. temperatureThe mixture was then cooled slightly
  4. filtrationThis mixture was filtered
  5. washthe solid washed with 25 ml
  6. dry with materialof cold water and dried

Sources & evidence

ORD record
ord-801fe3d5f4004a90b1303aeae18122b9
Source dataset
uspto-grants-1987_04
Patent number
US04656168

Reaction notes

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