Ethyl chloroformate → HCID 20209483, compound

HRID 542183Notes

Reaction equation

HRID 542183 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:18]2[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=2)[CH2:9][CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[CH:4][CH:3]=1.[Cl:25][C:26]([O:28][CH2:29][CH3:30])=[O:27].[OH-].[Na+]>C(Cl)(Cl)Cl.O>[ClH:25].[C:26]([N:15]1[CH2:14][CH2:13][N:12]([CH2:11][CH2:10][CH2:9][CH:8]([C:5]2[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=2)[C:18]2[CH:19]=[CH:20][C:21]([F:24])=[CH:22][CH:23]=2)[CH2:17][CH2:16]1)([O:28][CH2:29][CH3:30])=[O:27]

Participants

6

Reactant 3

HCID 10928Ethyl chloroformateHCID 14798Sodium HydroxideHCID 797291-(4,4-Bis(4-fluorophenyl)butyl)piperazine

Product 1

HCID 20209483HCID 20209483, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6212ChloroformSolvent2×

Procedure

To a solution of 3.3 g (0.01 mole) of 1-[4,4-bis(p-fluorophenyl)butyl]piperazine in 10 ml of CHCl3 was added dropwise over a period of 15 minutes 1.2 g (0.011 mole) of ethyl chloroformate in 10 ml of CHCl3. The mixture was refluxed for 2 hours and was made basic with 0.8 g of sodium hydroxide in 25 ml of water.

Workup

  1. temperatureThe mixture was refluxed for 2 hours

Sources & evidence

ORD record
ord-c440bfb63da54f03ab6fc20d5f589279
Source dataset
uspto-grants-1987_04
Patent number
US04656175

Reaction notes

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