1-[Bis(hydroxymethyl)-methyl]-6,7-diethoxy-3,4-dihydroisoquinoline → 2-(6,7-Dimethoxy-1,2,3,4-tetrahydro-isoquinolin-1-yl)-propane-1,3-diol

HRID 542194Notes

Reaction equation

HRID 542194 reaction equation
[OH:1][CH2:2][CH:3]([CH2:20][OH:21])[C:4]1[C:13]2[C:8](=[CH:9][C:10]([O:17][CH2:18]C)=[C:11]([O:14][CH2:15]C)[CH:12]=2)[CH2:7][CH2:6][N:5]=1>C1C=CC=CC=1>[OH:1][CH2:2][CH:3]([CH2:20][OH:21])[CH:4]1[C:13]2[C:8](=[CH:9][C:10]([O:17][CH3:18])=[C:11]([O:14][CH3:15])[CH:12]=2)[CH2:7][CH2:6][NH:5]1

Participants

3

Reactant 1

HCID 136966821-[Bis(hydroxymethyl)-methyl]-6,7-diethoxy-3,4-dihydroisoquinoline

Product 1

HCID 136966832-(6,7-Dimethoxy-1,2,3,4-tetrahydro-isoquinolin-1-yl)-propane-1,3-diol

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

The 6,7-diethoxy analogue of the above compound can be prepared in an analogous manner, starting from 1-[bis(hydroxymethyl)-methyl]-6,7-diethoxy-3,4-dihydroisoquinoline; melting point: 127° to 128 C.° (benzene).

Sources & evidence

ORD record
ord-ecb2e419a5f74823a25e7827ad07995e
Source dataset
uspto-grants-1987_04
Patent number
US04656179

Reaction notes

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