Hydrogen Bromide → 1-[Bis(hydroxymethyl)-methyl]-6,7-dihydroxy-3,4-dihydroisoquinoline hydrobromide

HRID 542195Notes

Reaction equation

HRID 542195 reaction equation
[OH:1][CH2:2][CH:3]([CH2:18][OH:19])[C:4]1[C:13]2[C:8](=[CH:9][C:10]([O:16]C)=[C:11]([O:14]C)[CH:12]=2)[CH2:7][CH2:6][N:5]=1.[BrH:20]>>[BrH:20].[OH:1][CH2:2][CH:3]([CH2:18][OH:19])[C:4]1[C:13]2[C:8](=[CH:9][C:10]([OH:16])=[C:11]([OH:14])[CH:12]=2)[CH2:7][CH2:6][N:5]=1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 136966801-[Bis(hydroxymethyl)-methyl]-6,7-dimethoxy-3,4-dihydroisoquinoline

Product 1

HCID 1358024291-[Bis(hydroxymethyl)-methyl]-6,7-dihydroxy-3,4-dihydroisoquinoline hydrobromideYield 82%

Procedure

0.01 mole (2.65 g) of 1-[bis(hydroxymethyl)-methyl]-6,7-dimethoxy-3,4-dihydroisoquinoline is boiled with 10 ml of a 46% hydrogen bromide solution for 4 hours. The mixture is evaporated and the residue is triturated with acetone to yield the aimed compound.

Workup

  1. customThe mixture is evaporated
  2. customthe residue is triturated with acetone

Sources & evidence

ORD record
ord-3a6b1fcb6bdb4ae0bee5de23083f1803
Source dataset
uspto-grants-1987_04
Patent number
US04656179

Reaction notes

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