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A crude reaction mixture of N-acetyliminodiacetic acid was prepared from acetamide (5.90 g; 0.10 mol)) by the process described in French Pat. No. 2,523,576. This crude product was dissolved in a 20% aqueous hydrochloric acid solution and the resulting mixture was added to a 250 ml 3-necked flask equipped with an addition funnel and thermometer. Phosphorous acid (8.61 g; 0.105 mol) was added and the solution was heated to a temperature of 106° C.-107° C. When this temperature had been reached, formaldehyde (8.23 g of a 44% aqueous solution; 0.212 mole) was added to the mixture in the flask over a period of 30 minutes. After addition of formaldehyde was complete, the temperature was maintained at 106°-107° C. for an additional period of 3.5 hour. The reaction mixture was concentrated under reduced pressure and a precipitate formed. The product was collected by filtration to yield 14.4 g of N-phosphonomethyliminodiacetic acid (63% yield based on the starting amount of acetamide).

1. additionthe resulting mixture was added to a 250 ml 3-necked flask
2. customequipped with an addition funnel
3. temperaturethe solution was heated to a temperature of 106° C.-107° C
4. addition0.212 mole) was added to the mixture in the flask over a period of 30 minutes
5. temperaturethe temperature was maintained at 106°-107° C. for an additional period of 3.5 hour
6. concentrationThe reaction mixture was concentrated under reduced pressure
7. customa precipitate formed
8. filtrationThe product was collected by filtration