Hydrogen Bromide → 5-(4-Aminophenyl)-6-methylpyrazin-2(1H)-one--hydrogen bromide (1/1)

HRID 542448Notes

Reaction equation

HRID 542448 reaction equation
C(OC([NH:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[N:19]=[CH:20][C:21](=[O:25])[NH:22][C:23]=2[CH3:24])=[CH:14][CH:13]=1)=O)C1C=CC=CC=1.[BrH:26].C(O)C>C(O)(=O)C>[BrH:26].[NH2:11][C:12]1[CH:13]=[CH:14][C:15]([C:18]2[N:19]=[CH:20][C:21](=[O:25])[NH:22][C:23]=2[CH3:24])=[CH:16][CH:17]=1

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 702EthanolHCID 13853563HCID 13853563, compound

Product 1

HCID 202086665-(4-Aminophenyl)-6-methylpyrazin-2(1H)-one--hydrogen bromide (1/1)

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

5-(4-Benzyloxycarbonylaminophenyl)-6-methyl-2(1H)-pyrazinone (0.5 g) was treated with hydrogen bromide in acetic acid in a manner similar to that described in Example 20 to give the title compound as its hydrobromide salt (340 mg) which after digestion with hot ethanol had m.p. >300° C.; δ(D2O) inter alia 2.39 (3H, d, CH3), 8.03 (1H, q, pyrazinone ring 3-H); ν(KBr) 1705, 1750 cm-1.

Sources & evidence

ORD record
ord-492043e7db4346358dcc8fd9202d6981
Source dataset
uspto-grants-1987_04
Patent number
US04657906

Reaction notes

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