Hydrochloric Acid → N-(2-Aminoethyl)-N'-[4-(5-oxo-4,5-dihydropyrazin-2-yl)phenyl]urea

HRID 542469Notes

Reaction equation

C([NH:4][CH2:5][CH2:6][NH:7][C:8](=[O:23])[NH:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[N:17]=[CH:18][C:19](=[O:22])[NH:20][CH:21]=2)=[CH:12][CH:11]=1)(=O)C.Cl>>[NH2:4][CH2:5][CH2:6][NH:7][C:8](=[O:23])[NH:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[N:17]=[CH:18][C:19](=[O:22])[NH:20][CH:21]=2)=[CH:12][CH:11]=1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 13853582HCID 13853582, compound

Product 1

HCID 20208658N-(2-Aminoethyl)-N'-[4-(5-oxo-4,5-dihydropyrazin-2-yl)phenyl]urea

Procedure

5-[4-(3-(2-Acetamidoethyl)ureido)phenyl]-2(1H)-pyrazinone was hydrolysed by heating with hydrochloric acid to form the title compound, as the hydrochloride; δ(D2O/DCl) 3.15, 3.45 (2t, 4H, --CH2CH2 --), 7.81, 8.08 (2d, pyrazinone H's).

Sources & evidence

ORD record: ord-46add1542d354b988628372066aad9ad
Source dataset: uspto-grants-1987_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04657906

Reaction notes

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