反应详情

In a manner similar to Example 13b, 5-[4-(isocyanato)phenyl]-2(1H)-pyrazinone was reacted with 2-hydroxyethylamine (0.5 g) in dimethylformamide (5 ml) for 17 hours at room temperature. The mixture was purified by flash chromatography (chloroform--20% methanol/80% chloroform); the desired fractions were combined and evaporated under reduced pressure to affored a residue. This residue was washed with chloroform and dried to form the title compound; δ(DMSO-d6) 3.17 (sextet, 2H, --NHCH2), 3.47 (t, 2H, --CH2OH), 7.94, 8.06 (2d, J=1 Hz, pyrazinone H's).

1. customThe mixture was purified by flash chromatography (chloroform--20% methanol/80% chloroform)
2. customevaporated under reduced pressure
3. washThis residue was washed with chloroform
4. customdried